Cisplatin resistance and pd-l1

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August undefined, 2024

WebApr 11, 2024 · BackgroundProgrammed cell death-ligand 1 (PD-L1) inhibitors plus chemotherapy have made substantial progress in extensive-stage small-cell lung cancer (ES-SCLC), but the survival benefit is still limited. This study aimed to evaluate the preliminary efficacy and safety of camrelizumab plus platinum-irinotecan (IP/IC) followed … WebAug 6, 2024 · PD-L1 binding to PD-1 could negatively regulate the signals of T cell receptor (TCR), reducing TCR-mediated proliferation and production of cytokine. PD-L1 is a key protein that regulates the aggregation and clearance of …

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WebOct 13, 2024 · For example, cisplatin resistance sometimes correlates with the presence of wild type TP53 . ... High expression of CD274/PD-L1 combined with low expression of the histone deacetylase, ... WebOct 22, 2024 · Cisplatin is an alkylating agent which induces DNA damage through the formation of cisplatin-DNA adducts, leading to cell cycle arrest and apoptosis. In the management of advanced OSCC, cisplatin-based chemotherapy or chemoradiotherapy has been considered as the first-line treatment. memphis grizzlies ziaire williams

Elevated Cellular PD1/PD-L1 Expression Confers Acquired

WebImmune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of non–small cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic drugs may improve the efficacy of ICB in mouse tumor models and patients with cancer. WebCisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells Immune tolerance is one of the leading causes of chemotherapy resistance in carcinoma cases. Web14 hours ago · Cisplatin treatment does not change the level of expression of EGFR and PD-L1. ... EVs, namely the tetraspanins CD9 and CD81 which are common EV markers … memphis hack club

Elevated Cellular PD1/PD-L1 Expression Confers Acquired …

WebJul 28, 2024 · PD-L1, the ligand of PD-1, expresses universally and increases in malignant cells [ 8 ]. Recent studies indicated that both PD-1 and PD-L1 contribute to cisplatin … WebThe interaction between programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) inhibits T-cell activation and proliferation. 4, 5 Several previous studies have reported that PD-L1 overexpression is a predictor of a poor clinical outcome in patients with NSCLC. 6 – 8 On the other hand, PD-L1 overexpression has been shown to be correlated with an … memphis grizzlies western conferenceWebPD-L1 increases resistance to radiation or cisplatin by stabilizing NBS1, BRCA1, and other proteins that facilitate the repair of DNA damage ( 5 ). PD-L1 also diminishes IFN-β cytotoxicity by inhibiting an IFN-β–induced STAT3/caspase-7–dependent pathway ( 6 ). memphis group aesthetic

"WebSteven G. Gray, in Epigenetic Cancer Therapy, 2015 3.3 EZH2/PRC2 Complexes and Cisplatin Resistance. One of the first indicators that the lysine methyltransferase EZH2 … " - Cisplatin resistance and pd-l1

Cisplatin resistance and pd-l1

Cisplatin resistance: a cellular self-defense mechanism

WebCisplatin is one of the most effective broad-spectrum anticancer drugs. Its effectiveness seems to be due to the unique properties of cisplatin, which enters cells via multiple … http://mars.gmu.edu/handle/1920/13265?show=full

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WebApr 10, 2024 · Investigating PD-1/PD-L1 Checkpoint Inhibition as a Treatment for Platinum-Resistant Ovarian Cancer Show simple item record Files in this item Name: Carter_gmu_0883E_ ... Size: 15.07Mb Format: PDF View/ Open This item appears in the following Collection (s) College of Science Show simple item record WebApr 10, 2024 · Several therapeutically relevant markers were identified in EVs collected after cisplatin treatment, including PD-L1 and other proteins regulating PD-L1 export. …

WebSep 9, 2016 · Here we report that cell-intrinsic expression of PD1 and PD-L1, two immune checkpoints, is required for sustained expansion of SCLC cells under cisplatin selection. Indeed, PD1 and PD-L1 were expressed at a higher level in lung cancer cell lines, tumor tissues, and importantly, in SCLC cells resistant to cisplatin (H69R, H82R), when … WebCAFs-derived IL-6 could upregulate CXCR7 in esophageal squamous cell carcinoma and promote resistance to cisplatin via the JAK/STAT3 pathway (Qiao ... T cell receptor-mediated activation rapidly induces PD-1 expression. PD-L1/PD-1 can be regulated by the following signaling pathways in the TME: PI3K/AKT pathway, NF-κB pathway, WNT …

WebNov 23, 2024 · It was reported that the combined administration of anti-PD-L1 antibodies and DDP significantly reduced tumor growth compared with single-agent treatments and controls . These findings indicated a key role of PD-L1 in regulating DDP resistance of cancer cells. The survival and proliferation of cancer cells require the expression of cyclin … WebCisplatin is one of the most effective broad-spectrum anticancer drugs. Its effectiveness seems to be due to the unique properties of cisplatin, which enters cells via multiple …

WebMay 28, 2024 · PD-L1 is critical for tumor cell escape from immune surveillance by inhibiting T cell function via the PD-1 receptor. Accumulating evidence demonstrates that anti-PD-L1 monoclonal antibodies might potently enhance antitumor effects in various tumors, but the effect of PD-L1 on colorectal cancer stem cells (CSCs) remains unclear.

WebApr 14, 2024 · Autophagy Influences Hypoxia, Chemoresistance, and Stem-like Phenotype in Breast Cancer It is known that cancer stem cells are a significant contributor to the development of chemoresistance in breast cancer [ 88, 89, 90, 91 ]. Autophagy enables the survival of CSCs under hypoxia in the tumor microenvironment [ 92 ]. memphis group furnitureWebOct 21, 2024 · Knockdown of KIFC1 by siRNA increased the sensitivity to cisplatin in BC cells. Kaplan-Meier analysis indicated that prognosis was poor among KIFC1 -positive BC patients treated with cisplatin-based chemotherapy. Immunohistochemistry showed that KIFC1 -positive cases were associated with PD-L1-positive cases. memphis grizzly logoWebApr 13, 2024 · Consequently, miR-196a released from exosomes can confer cisplatin resistance to cancer cells by novel binding targets, CDKN1B and ING5, demonstrating that miR-196a could be a potential predictor ... memphis gym floorWebAug 3, 2024 · Background: Non-small cell lung cancer (NSCLC) cells derived intracellular and extracellular programmed cell death ligand 1 (PD-L1) promoted cancer progression and drug resistance, and facilitated tumor immune evasion. However, the detailed molecular mechanisms are still largely unknown. memphis growler stationsWeb14 hours ago · The results indicate that in contrast to erlotinib and cisplatin, osimertinib treatment increased a subset of the HER2 and PD-L1 positive EV population. However, the average expression of the two proteins on individual EVs was found to … memphis gun show 2020WebSep 18, 2024 · NCBI Bookshelf memphis habitat for humanity memphis hadestown