High affinity copper uptake protein 1-like

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August undefined, 2024

Web1 de jan. de 2024 · This high-affinity copper transporter takes up Cu + from the intestinal lumen to the epithelial cell, in an energy-independent manner [2], [3]. CTR1 is the major copper importer present on the apical site of enterocytes, but conflicting reports have also shown a possible role of DMT1 in copper transfer into intestinal cells. WebHigh affinity copper uptake protein 1: Synonyms: Copper transporter 1; Solute carrier family 31 member 1; hCTR1; Gene Name: SLC31A1: Protein Type: Transporter: Biological Properties; ... structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture.

Characterization of the Saccharomyces cerevisiae High Affinity Copper ...

WebHigh affinity copper uptake protein 1 is a protein that in humans is encoded by the SLC31A1 gene.[5][6] For faster navigation, this Iframe is preloading the Wikiwand page … WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at … graphing a csv file

Molecular Characterization of hCTR1, the Human Copper Uptake Protein*

Web1 de abr. de 2024 · Inducible high-affinity copper uptake is key to copper homeostasis in Chlamydomonas reinhardtii. We generated cDNAs and updated gene models for four genes, CTR1, CTR2, CTR3, and COPT1, encoding ... WebGene ID: 102804936, updated on 5-Feb-2024. Summary Other designations. high affinity copper uptake protein 1-like WebHuman CTR1 is a high-affinity copper transporter that also mediates the uptake of the anticancer drug cisplatin by largely unknown transport mechanisms. Here we report the 6 … graphing a circle on a ti 84 plus

Recent advances in the modulation of amyloid protein …

A re-evaluation of the role of hCTR1, the human high-affinity copper ...

WebCopper is an essential cofactor for key processes in plants, but it exerts harmful effects when in excess. Previous work has shown that the Arabidopsis (Arabidopsis thaliana) COPT1 high-affinity copper transport protein participates in … Web30 de mar. de 2024 · Functional assays revealed that it stimulates the initial rate of radiolabeled copper uptake. CTR1 transports copper with high affinity in a time-dependent and saturable manner and is copper-specific. Transport is an energy-independent process and is stimulated by extracellular acidic pH and high K+ … chirp and dalesWebencode a high affinity copper uptake process and was found to be 29% identical at the primary structure level with Ctr1 from yeast. The human protein was, however, substantially smaller than the yeast protein, being composed of 190 amino acids as compared with 406 amino acids (see Fig. 1). hCTR1 is on the graphing a circle function

"WebBecause copper uptake at the cell membrane is a crucial step in copper acquisition, yeast genes encoding the high affinity copper transport proteins are tightly regulated in response to copper levels to ensure … " - High affinity copper uptake protein 1-like

High affinity copper uptake protein 1-like

High affinity copper uptake protein 1 (pig) - PubChem

WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function Web9 de jun. de 2024 · ATP7A, copper-transporting ATPase 1; ATP7B, copper-transporting ATPase 2; ATOX1, copper transport protein ATOX1; BBB, blood-brain barrier; CCS, copper chaperone for superoxide dismutase; CNS, central nervous system; CP, ceruloplasmin; CTR1, high affinity copper uptake protein 1; CTR2, probable low …

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Web22 de ago. de 2024 · Crystal structure of the high-affinity copper transporter Ctr1 in complex with Cu (I) PDB DOI: 10.2210/pdb6M98/pdb Classification: TRANSPORT PROTEIN Organism (s): Salmo salar, Escherichia coli Expression System: Komagataella phaffii GS115 Mutation (s): Yes Membrane Protein: Yes PDBTM MemProtMD mpstruc … WebCopper is imported into eukaryotic cells through high-affinity copper transporters of the family of Ctr permeases. 9 To date, Ctr transporters are the best-characterized system …

Web1 de abr. de 2002 · Copper uptake High-affinity copper transport proteins Physiological and biochemical studies many years ago suggested the presence of at least two independent activities responsible for copper uptake in eukaryotic cells, of distinct affinities and capacities for copper [6]. Web27 de mar. de 2024 · Copper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. …

Web10 de abr. de 2024 · Abstract Heavy metal contamination impacts plant growth and productivity by causing damage at all levels of plant organization, making it one of the most significant abiotic stressors. This study evaluated the uptake and distribution of cadmium (Cd) and copper (Cu) in Solanum lycopersicum L. and identified the antioxidant enzyme … Web11 de mai. de 2024 · At physiological pH, NGF peptides bind one equivalent of copper ion with higher affinity of Aβ and lower than hCtr1 peptide fragments. Therefore, in the synaptic cleft, NGF may act as a potential copper chelating molecule, ionophore or chaperone for hCtr1 for metal uptake.

Web7 de mai. de 2024 · Cuprizone administration induces mitochondrial enlargement, severely alters metabolic rates, and impairs oxidative phosphorylation by reducing mitochondrial enzymes that contain copper as a cofactor, such as monoamine oxidase [ 27] and cytochrome c (Cyt c) oxidase [ 28, 29] in the brain of mice.

WebGene ID: 100178573, updated on 26-Oct-2024. Summary Other designations. high affinity copper uptake protein 1-like chirp and whimsyWeb11 de abr. de 2024 · Several lines of evidence presented here strongly suggest that the first histidine (His43) upstream from TMD1 is absolutely required for the copper transport activity of COPT1 protein. Firstly, deletion of 43 residues, but not 41 residues, of the extracellular N-terminus, completely blocked high affinity copper uptake of COPT1. chirp and peep and quackWeb27 de mar. de 2024 · The high-affinity Cu transporter Ctr1 ( Km ≈ 2 μM) 4, an integral membrane protein localized to the plasma membrane and endosomal vesicles, mediates cellular Cu uptake in eukaryotes from... chirp and oink santa claritaWebThe affinity measured by Km value for the drugs transported by their corresponding DTs were unified to the unit of micromolar 4. 2D and 3D Structures of Small Molecular Drugs The structures of the small molecular drugs transported by DTs were drawn and were standardized in the .sdf format (both 2D and 3D) 5. chirp and peep videosWeb16 de mar. de 2010 · Copper and iron are essential elements employed in pathways that are conserved in all kingdoms of life. In eukaryotes, several interdependent connections between copper and iron homeostasis have been described previously ().For example, high-affinity iron uptake in Saccharomyces cerevisiae is mediated by multicopper … chirp androidWebTransport of ferrous iron (Fe 2+). Fe 2+ uptake is carried out by proteins involved in high-affinity uptake systems and general divalent metal ion transporters. The two most widely distributed eukaryotic divalent metal-ion uptake protein families are Natural Resistance Associated Protein (NRAMP) and Zinc-Regulated Transporter (ZRT)-Iron-Regulated … graphing a complex numberWeb8 de abr. de 2024 · Water soluble CB[7]-PEG conjugate still maintains a high affinity for the N-terminal Phe of insulin (K d = 2.1 ± 0.3 μM) like unmodified CB[7]. The pendant PEG chain of at least 30 kDa in CB[7]-PEG conjugate didn't alter the affinity due to steric hindrance of CB[7] for insulin. chirpan facebook